Nasal Carcinogenesis in Rodents

Revelance to Human Health Risk Proceedings of the Tno-Civo/Nyu Nose Symposium
  • 252 Pages
  • 4.42 MB
  • 1876 Downloads
  • English
by
Pudoc
Animal pathology & diseases, Medical research, Oncology, Carcinogenesis, Health/Fi
ContributionsM. C. Bosland (Editor)
The Physical Object
FormatHardcover
ID Numbers
Open LibraryOL12799945M
ISBN 109022009823
ISBN 139789022009826

Nasal Tumors in Animals and Man Vol. III () Pages pages This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals. and in the rodents which are commonly employed in carcinogenesis studies in the : Gerd Reznik, Sherman F.

Stinson. The pathological features of nasal neoplasia in rats, mice, and hamsters has been extensively reviewed (Brown et al. ; Feron and Bosland ; Feron et al. ; Reznik and Stinson ). Tumors have been recorded for each of the major nasal epithelial types and a number of accessory structures, and some of these neoplasms are the subject of recent research on mechanisms of carcinogenesis.

This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the : Gerd Reznik, Sherman F.

Stinson. The report that inhaled formaldehyde induced nasal squamous cell carcinomas in rats had a significant societal impact and resulted in extensive research in the fields of rodent nasal pathology and human cancer risk assessment. This article presents an overview of the evolution of these by: Inhalation carcinogenesis studies in rodents, with no-observed-adverse-effect levels (NOAELs) of and ppm, have revealed that chronic, high exposure to PO can induce tumors at the site of.

Revival: Nasal Tumors in Animals and Man Vol. III (): Experimental Nasal Carcinogenesis - CRC Press Book This Monograph brings together within one cover the Nasal Carcinogenesis in Rodents book knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals.

and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.

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Although tumors of the nasal cavity are far less common in humans than cancers at other organ sites such as lung and breast, many nitrosamines are nasal cavity carcinogens in laboratory rodents.

For a list of nitrosamines which are nasal cavity carcinogens, the reader is referred to and. In extrapolating such data to human carcinogenesis, it is often overlooked that with respect to the cell types present, the rodent lung Cited by: 6.

Experimental Nasal Carcinogenesis. Nasal Tumors in Animals and Man Vol. III () Nasal Tumors in Animals and Man Vol. III () book. Experimental Nasal Carcinogenesis. Edited By Gerd Reznik, Sherman F.

Stinson. Edition 1st Edition.

Description Nasal Carcinogenesis in Rodents FB2

Nasal Carcinogenesis in Rodents book Published eBook Published 22 November Pub. location Boca Raton. Imprint CRC : Y. Zeng. This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.

In two studies in rats NMPz showed a carcinogenic effect in the nasal region only after very high dosages (5 – 7), but it was evaluated as negative in two rodent bioassays (3, 4). However, NMPz was reported to be mutagenic in several short-term tests (8 – 16).Cited by: 9.

In the rat, adenocarcinomas of the upper respiratory epithelium are found almost exclusively in the nasal cavities, few having been reported in the larynx or trachea. Adenocarcinomas in the anterior nasal cavities arise most frequently from the epithelium lining the naso- and maxilloturbinals and the nasal septum (Fig.

99).Cited by: 2. The esophagus and nasal cavity were common sites for neoplasms induced by nitrosodi-n-propylamine, but neoplasms of the bladder, lung and forestomach were commonly seen only in the rats treated with nitrosodi-n-butylamine. The bladder neoplasms were transitional cell carcinomas, those of the esophagus and forestomach were papillomas and by: Book Description.

This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.

I (): Anatomy, Physiology, and Epidemiology - CRC Press Book Revival: Nasal Tumors in Animals and Man Vol. This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the.

All 12 of these chemicals produced nasal tumors in rats, and 5 also produced nasal tumors in mice. Most of the nasal carcinogens (1) produced tumor increases in both sexes, (2) produced tumors at other sites as well, (3) had significantly reduced survival at doses that were carcinogenic, and (4) were by:   Four groups of 30 F rats were exposed to MCS ( mg total particulate matter/m3) or filtered air for 2 or 8 weeks.

Western analysis of microsomes from nasal tissue of MCS-exposed rats showed an induction of CYP1A1 in respiratory and olfactory mucosae, as well as liver, kidney and by: The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer.

The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-specific cell turnover by: Cancer Letters, 57 () Elsevier Scientific Publishers Ireland Ltd.

95 Inhalation of tetranitromethane causes nasal passage irritation and pulmonary carcinogenesis in rodents J.R. Bucher', J.E.

Huff', M.P. Jokinen', J.K. Haseman', M. Stedhamb and J.M.

Details Nasal Carcinogenesis in Rodents EPUB

Cholakisc 'National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Cited by: In the nasal epithelium of F rats, DNA-protein crosslinks were still detected at formaldehyde concentrations as low as ppn (47).

42 In rats exposed. Inhalation of naphthalene causes olfactory epithelial nasal tumors in rats (but not in mice) and benign lung adenomas in mice (but not in rats).

The limited available human data have not identified an association between naphthalene Cited by: This report gives the rationale, criteria, and guidelines used by the NTP for combining neoplasms for the evaluation of long-term rodent toxicology and carcinogenesis studies.

The guidelines are based mainly on lesions occurring in the F/N inbred rat and (C57BL/6 x C3H)F 1 mouse and may or may not be appropriate for other strains or by: Nasal Tumors in Animals and Man Volume III () This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals.

and in the rodents which are commonly employed in carcinogenesis studies in the laboratory. In rodent carcinogenesis experiments, chronic toxic lesions, accompanied by increases in normal levels of cell turnover, have sometimes been observed in target organs of nongenotoxic carcinogens.

More often, however, organ-specific nongenotoxic toxins are not carcinogens. These toxins include compounds toxic for the liver, kidney, and nasal by:   Carcinogenesis studies were conducted in groups of 50 male F/N rats and 50 female B6C3F1 mice exposed to a mixture of m and p cresols (m-/p-cresol) in feed.

Rats and mice were fed diets containing 0, or 15, ppm and 0, or 10, ppm, by: Rice JM, Rehm S, Donovan PJ, Perantoni AO () Comparative transplacental carcinogenesis by directly acting and metabolism-dependent alkylating agents in rodents and nonhuman primates.

In: Napalkov NP, Rice JM, Tomatis L, Yamasaki H (eds) Perinatal and multigeneration carcinogenesis. I ARC Sci Publ –34 Google Scholar. This article has been cited by other articles in PMC. Research on nickel carcinogenesis from to March is reviewed. Epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of cancers of the nasal cavities and by: Another way of transferring groups of mice or individ-uals, is by using a glass or synthetic bowl.

The vessel is brought close to the mice with its open end directed P ROCEDURES H ANDLING AND R ESTRAINT Figure Grasping a group of C57BL/6 mice.

Figure Carrying a group of C57BL/6 mice in the cupped hand. This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the : CRC Press.

Formaldehyde is one of the most studied genotoxic nasal carcinogen in rodents. In rats, formaldehyde causes nasal squamous cell carcinomas in a concentration-dependent manner that parallels the formation of DNA-protein crosslinks and adducts (Heck et.

Carcinogenesis studies were conducted in groups of 50 male F/N rats and 50 female B6C3F1 mice exposed to a mixture of m- and p-cresols (m-/p-cresol) in feed.

"This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals. and in the rodents which are commonly employed in carcinogenesis studies in the laboratory."--Provided by publisher.Unlike other species, rodents do not have organized tonsils or Waldeyer's ring, but they have nasal lymphoid tissue in the ventrocaudal region of the nasal cavity, at .Another study led by Ottolenghi focused on pulmonary carcinogenesis in rats after chronic inhalation of nickel sul de [ 38 ].

and F rats .